Vertebrate organ development is an intricate process that begins in the early embryo and continues until the functional capacity of the organ meets adult requirements. Relatively little is known about ...

Cardiovascular disease continues to lead as the primary cause of death across the globe, taking millions of lives every year. Damage caused by these diseases is particularly difficult to repair, since ...

The high cost associated with developing new chemical entities (NCEs) creates a clear demand for better prediction of toxicity and efficacy to thus enable more effective SAR early in the discovery ...

Heart muscle cells grown from patient stem cells—known as human induced pluripotent stem cell–derived cardiomyocytes, or hiPSC-CMs—are a promising way to repair hearts damaged by heart attacks and ...

“For decades, researchers have been trying to find the specialized cells that make new muscle cells in the adult heart, and we think that we have found that cell,” Hesham Sadek, the senior author of ...

University of Alabama at Birmingham researchers, led by Jianyi “Jay” Zhang, M.D., Ph.D., and Lei Ye, M.D., Ph.D., generated the human leukocyte antigen-knockout ...

Cardiotoxicity underlies a third of failures in regulatory clearance, making it among the most significant hurdles in developing new drugs. 1 axoCells human iPSC-derived ventricular cardiomyocytes ...

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) say that it is now possible for the first time to monitor the functional development and maturation of ...