August 30, 2007 (Farmingham, CT) – A new mouse study published this week provides some insight into understanding why rofecoxib (Vioxx, Merck) and the other cyclooxygenase (COX)-2 inhibitors increase ...

Eicosanoid pathways have a major role in the pathogenesis of rheumatic diseases, including rheumatoid arthritis, osteoarthritis, idiopathic inflammatory myositis, systemic lupus erythematosus and ...

Reducing Xerostomia by IMRT: What May, and May Not, Be Achieved Since 1992, there have been approximately 10,962 COX-2–related publications and many studies of human cancer have associated its ...

A potentially valuable new study discusses the role of lipids in the hyper-inflammatory phenomena that take place within the lungs of patients with severe or critical COVID-19. Involving a large ...

Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway ...

COX-2 plays a pivotal role in ferroptosis during the progression of chronic liver disease, as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ferrous ...