Adopting a Quality by Design (QbD) approach for wet granulation requires manufacturers to comprehend the correlation between process variables, such as powder characteristics and equipment ...

Granulation is a critical unit operation in pharmaceutical manufacturing, where fine powders are agglomerated into granules to improve flow properties, uniformity, and compaction performance. The ...

Formulating drugs to ensure therapeutic consistency, enable rapid development, and allow for cost-effective scale-up has become increasingly challenging. This is especially true in the context of ...

At the manufacturing level, pharmaceutical manufacturers are leveraging advanced technologies and automation to address challenges such as sample under fill and overfill, detect contaminants and other ...

Pharmaceutical manufacturing practices are advancing towards a future in which continuous manufacturing processes will be the norm. Developing and applying such techniques is therefore an essential ...

In dry granulation, powders bind because of the application of mechanical stress. As particles are forced to be within closer proximity, entrained air is forced out, bulk density increases, and a ...

FDA researchers present case studies using soft sensors to predict critical quality attributes and monitor crystallinity and ...