BX-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1), but also a potent inhibitor of the IKK-related kinase, TANKbinding kinase 1 (TBK1) and IKKÉ›. In this study we attempted to ...
Discovered in the 1990s, the JNK protein, or, to give it its full name, c-Jun NH 2-terminal kinase, was found to be the protein kinase responsible for the phosphorylation of c-Jun at Ser-63 and Ser-73 ...
Mitogen-activated protein kinase (MAPK) networks are essential for the transmission of extracellular signals into appropriate intracellular responses. Prototypical MAPK activation implements a ...
Spatial transcriptomic and proteomic insight into Trop-2, HER2, and AR expression: A pathway to tailored therapies in triple-negative breast cancer. This is an ASCO Meeting Abstract from the 2024 ASCO ...
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