One such chemical modification is cytidine acetylation (N4-acetylcytidine). Until now, the precise function of this chemical modification within cells has not been clearly understood. In particular, ...

Scientists know that TDP-43, which helps regulate processing of RNA, may be responsible for the death of nerve cells in ALS and frontotemporal dementia. And a study suggests that a common modification ...

Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown ...

After a gene is transcribed into RNA, modifications can occur to the subunits or "bases" that make up the RNA molecule, which can affect its structure and function. The study of these changes is known ...

Cells contain a blueprint in the form of DNA that dictates what they can make. This blueprint is converted into a message, or mRNA, which is then converted into protein. Although DNA remains the same ...

A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells' protein-making machinery may offer protection against non-alcoholic fatty liver, a ...

An RNA modification may offer protection against non-alcoholic fatty liver, a condition that results from a build-up of fat in the liver and can lead to advanced liver disease, according to a new ...

To overcome these limitations, the research team developed a "targeted RNA acetylation system (dCas13-eNAT10)" by combining Cas13, gene scissors that precisely target desired RNA, with a hyperactive ...

Nearly 100% of cases of amyotrophic lateral sclerosis—the progressive, fatal neurodegenerative disease known as ALS or Lou Gherig’s disease — involve the buildup of a protein called TDP-43. Scientists ...