Scientists show that neutralizing liver-derived ApoE protein reverses age-related delays in bone fracture healing ...

Bones have important endocrine and paracrine roles beyond their structural function. Bone mass and integrity is determined by the opposing activities of osteoblasts (which make bone) and osteoclasts ...

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects ...

Wif1 overexpression accelerated osteogenic differentiation by activating genes related to late-stage osteogenic differentiation and mitophagy processes. Moreover administering Wif1-overexpressing ...

Parathyroid hormone shows promise in treating low back pain by remodeling degenerating vertebral endplates and limiting ...

Although current evidence suggests that only a minuscule number of osteoblast-lineage cells are present in peripheral blood, we hypothesized that such cells circulate but that their concentration has ...

Osteoporosis is the primary cause of bone fractures in the elderly, reflecting an imbalance between osteoclasts, bone-degrading cells, and osteoblasts, bone-building cells. Teriparatide is the only ...

Osteoporosis or the weakening of bones makes the aging population vulnerable to fractures and a decreased quality of life. The parathyroid hormone (PTH)-derived peptide -- teriparatide has ...