Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

Researchers at the John Innes Center and the Earlham Institute are pioneering powerful single-cell visualization techniques ...

Saurabh Sinha (center) and his collaborators are advancing the field of spatial transcriptomics with development of InSTAnT. Flanking Sinha are trainees from his lab (left to right), Bhavay Aggarwal ...

This figure shows how the STAIG framework can successfully identify spatial domains by integrating image processing and contrastive learning to analyze spatial transcriptomics data effectively.

Technological development is key to improving the way hematologic cancer is diagnosed and treated. With this vision, the Josep Carreras Leukemia Research Institute is committed to the creation and ...

Spatial transcriptomics (ST) technologies reveal the spatial organization of gene expression in tissues, providing critical insights into development, neurobiology, and cancer. However, the high cost ...

Spatial ribonucleic acid (RNA) transcriptomics measures gene expression while preserving each molecule’s coordinates in intact tissue, tying transcripts to histology and local microenvironments.

Strapped with an extra APP, people with Down’s syndrome are all but destined to develop Alzheimer’s dementia if they live past middle age. Compared with sporadic forms of the disease, DSAD starts ...

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context. In musculoskeletal ...

Spatial maps of various tissues and organs in aging mice have revealed new insights into the aging process. Aging is a process common to many animals; however, the complexity of aging means that there ...