Feb 2, 2026 · In this issue of the JCI, Napolitano et al. analyzed tumor biopsies from patients with ER+ breast cancer and reported that endocrine-resistant tumors exhibited heightened CD8+ T cell …

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Jan 2, 2026 · View this article via: JCI CrossRef PubMed Google Scholar Bauer IJ, et al. Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging.

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Neutrophil extracellular traps (NETs) are associated with cancer progression; however, the functional role and clinical importance of NET-DNA in therapeutic resistance remain unclear. Here, we show …

Mar 18, 2025 · Aberrant RNA splicing is tightly linked to diseases, including metabolic dysfunction–associated steatotic liver disease (MASLD). In this study, we revealed that minor intron …

Jan 2, 2025 · In this issue of the JCI, Derakhshan et al. elucidate the heterogeneity of MCs in nasal polyposis and identify a transcriptional signature of TGF-β target genes expressed by the …

On October 1, 1924, the American Society of Clinical Investigation published the first issue of the JCI. Over the last 100 years, JCI ’s mission has been to provide a forum for research exploring …

Oct 1, 2025 · Ruling in, ruling out: the clinical utility of plasma biomarkers in diagnosis of Alzheimer’s disease Julie K. Wisch and Beau M. Ances