Though repeated facial expressions can cause wrinkles over time, Restylane® Refyne and Restylane® Defyne are clinically proven to soften laugh lines and help maintain natural expression (1,2,3). The most commonly observed side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, and itching at the injection site. To learn more about serious but rare side effects and full Important Safety Information, visit www.RestylaneUSA.com. 1. Data on file. 05DF1502 Clinical S
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